Back to Search
Start Over
Outcomes in neonates born to mothers with COVID-19 during the second wave in India.
- Source :
-
European journal of pediatrics [Eur J Pediatr] 2022 Sep; Vol. 181 (9), pp. 3537-3543. Date of Electronic Publication: 2022 Jul 08. - Publication Year :
- 2022
-
Abstract
- COVID-19 pandemic has affected all age groups globally including pregnant women and their neonates. The aim of the study was to understand outcomes in neonates of mothers with COVID-19 during the first and second waves of COVID-19 pandemic. A retrospective analysis of 2524 neonates born to SARS-CoV-2-infected mothers was conducted during the first wave (n = 1782) and second wave (n = 742) of the COVID-19 pandemic at five study sites of the PregCovid registry in Maharashtra, India. A significant difference was noted in preterm birth, which was higher in the second wave (15.0%, 111/742) compared to the first wave (7.8%, 139/1782) (P < 0.001). The proportion of neonates requiring NICU admission was significantly higher in the second wave (19.0%, 141/742) as compared to that in the first wave (14.8%, 264/1782) (P < 0.05). On comparing regional differences, significantly higher neonatal complications were reported from Mumbai metropolitan region (P < 0.05). During the second wave of COVID-19, birth asphyxia and prematurity were 3.8- and 2.1-fold higher respectively (P < 0.001). Neonatal resuscitation at birth was significantly higher in second wave (3.4%, 25/742 vs 1.8%, 32/1782) (P < 0.05). The prevalence of SARS-CoV-2 infection in neonates was comparable (4.2% vs 4.6%) with no significant difference between the two waves.<br />Conclusion: Higher incidence of adverse outcomes in neonates born to SARS-CoV-2-infected mothers in the second wave of COVID-19 as compared to the first wave.<br />Trial Registration: PregCovid study is registered with the Clinical Trial Registry of India (CTRI/2020/05/025423, Registered on 28/05/2020).<br />What Is Known: • The second wave of COVID-19 was more lethal to pregnant women than the first wave. Newborns are at risk of developing complications.<br />What Is New: • Birth asphyxia, prematurity, and neonatal resuscitation at birth were significantly higher in the second wave as compared to those in the first wave of the COVID-19 pandemic in India.<br /> (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Subjects :
- Asphyxia epidemiology
Female
Humans
India epidemiology
Infant, Low Birth Weight
Infant, Newborn
Infectious Disease Transmission, Vertical
Mothers
Pandemics
Pregnancy
Resuscitation
Retrospective Studies
SARS-CoV-2
COVID-19 epidemiology
Infant, Newborn, Diseases epidemiology
Pregnancy Complications, Infectious epidemiology
Premature Birth epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1076
- Volume :
- 181
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- European journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 35802208
- Full Text :
- https://doi.org/10.1007/s00431-022-04546-0