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Could respiration-driven blood oxygen changes modulate neural activity?

Authors :
Zhang Q
Haselden WD
Charpak S
Drew PJ
Source :
Pflugers Archiv : European journal of physiology [Pflugers Arch] 2023 Jan; Vol. 475 (1), pp. 37-48. Date of Electronic Publication: 2022 Jun 28.
Publication Year :
2023

Abstract

Oxygen is critical for neural metabolism, but under most physiological conditions, oxygen levels in the brain are far more than are required. Oxygen levels can be dynamically increased by increases in respiration rate that are tied to the arousal state of the brain and cognition, and not necessarily linked to exertion by the body. Why these changes in respiration occur when oxygen is already adequate has been a long-standing puzzle. In humans, performance on cognitive tasks can be affected by very high or very low oxygen levels, but whether the physiological changes in blood oxygenation produced by respiration have an appreciable effect is an open question. Oxygen has direct effects on potassium channels, increases the degradation rate of nitric oxide, and is rate limiting for the synthesis of some neuromodulators. We discuss whether oxygenation changes due to respiration contribute to neural dynamics associated with attention and arousal.<br /> (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Details

Language :
English
ISSN :
1432-2013
Volume :
475
Issue :
1
Database :
MEDLINE
Journal :
Pflugers Archiv : European journal of physiology
Publication Type :
Academic Journal
Accession number :
35761104
Full Text :
https://doi.org/10.1007/s00424-022-02721-8