Sex and cancer immunotherapy: Current understanding and challenges.

Authors :: Pala L
De Pas T
Catania C
Giaccone G
Mantovani A
Minucci S
Viale G
Gelber RD
Conforti F
Source :: Cancer cell [Cancer Cell] 2022 Jul 11; Vol. 40 (7), pp. 695-700. Date of Electronic Publication: 2022 Jun 23.
Publication Year :: 2022
Abstract: Recent evidence highlights patients' sex relevance in antitumor immune response through a complex interaction-among hormones, genes, behaviors, and the microbiome-that affects both innate and adaptive immune functions, as well as immune evasion mechanisms. These complex interactions ultimately influence the efficacy and toxicity of immune checkpoint inhibitors in solid tumors.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)