Back to Search
Start Over
Technical aspects of proton minibeam radiation therapy: Minibeam generation and delivery.
- Source :
-
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [Phys Med] 2022 Aug; Vol. 100, pp. 64-71. Date of Electronic Publication: 2022 Jun 21. - Publication Year :
- 2022
-
Abstract
- Proton minibeam radiation therapy (pMBRT) is a novel therapeutic strategy that combines the normal tissue sparing of sub-millimetric, spatially fractionated beams with the improved ballistics of protons. This may allow a safe dose escalation in the tumour and has already proven to provide a remarkable increase of the therapeutic index for high-grade gliomas in animal experiments. One of the main challenges in pMBRT concerns the generation of minibeams and the implementation in a clinical environment. This article reviews the different approaches for generating minibeams, using mechanical collimators and focussing magnets, and discusses the technical aspects of the implementation and delivery of pMBRT.<br /> (Copyright © 2022 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Protons
Glioma radiotherapy
Proton Therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1724-191X
- Volume :
- 100
- Database :
- MEDLINE
- Journal :
- Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
- Publication Type :
- Academic Journal
- Accession number :
- 35750002
- Full Text :
- https://doi.org/10.1016/j.ejmp.2022.06.010