Technical aspects of proton minibeam radiation therapy: Minibeam generation and delivery.

Authors :: Schneider T
Source :: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [Phys Med] 2022 Aug; Vol. 100, pp. 64-71. Date of Electronic Publication: 2022 Jun 21.
Publication Year :: 2022
Abstract: Proton minibeam radiation therapy (pMBRT) is a novel therapeutic strategy that combines the normal tissue sparing of sub-millimetric, spatially fractionated beams with the improved ballistics of protons. This may allow a safe dose escalation in the tumour and has already proven to provide a remarkable increase of the therapeutic index for high-grade gliomas in animal experiments. One of the main challenges in pMBRT concerns the generation of minibeams and the implementation in a clinical environment. This article reviews the different approaches for generating minibeams, using mechanical collimators and focussing magnets, and discusses the technical aspects of the implementation and delivery of pMBRT.<br /> (Copyright © 2022 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.)

Language :: English
ISSN :: 1724-191X
Volume :: 100
Database :: MEDLINE
Journal :: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Publication Type :: Academic Journal
Accession number :: 35750002
Full Text :: https://doi.org/10.1016/j.ejmp.2022.06.010

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