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Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents.

Authors :
Garello F
Svenskaya Y
Parakhonskiy B
Filippi M
Source :
Pharmaceutics [Pharmaceutics] 2022 May 26; Vol. 14 (6). Date of Electronic Publication: 2022 May 26.
Publication Year :
2022

Abstract

Targeted delivery of pharmaceuticals is promising for efficient disease treatment and reduction in adverse effects. Nano or microstructured magnetic materials with strong magnetic momentum can be noninvasively controlled via magnetic forces within living beings. These magnetic carriers open perspectives in controlling the delivery of different types of bioagents in humans, including small molecules, nucleic acids, and cells. In the present review, we describe different types of magnetic carriers that can serve as drug delivery platforms, and we show different ways to apply them to magnetic targeted delivery of bioagents. We discuss the magnetic guidance of nano/microsystems or labeled cells upon injection into the systemic circulation or in the tissue; we then highlight emergent applications in tissue engineering, and finally, we show how magnetic targeting can integrate with imaging technologies that serve to assist drug delivery.

Details

Language :
English
ISSN :
1999-4923
Volume :
14
Issue :
6
Database :
MEDLINE
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
35745705
Full Text :
https://doi.org/10.3390/pharmaceutics14061132