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Computed Tomography-Based Investigation on the Effects of Intravenous Bisphosphonate Administration on Tooth Growth in a Minipig Animal Model.

Authors :
Poxleitner P
Voss PJ
Steybe D
Seibert LM
Zeiter S
Stoddart MJ
Schmelzeisen R
Otto S
Source :
Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2022 Jun 09; Vol. 58 (6). Date of Electronic Publication: 2022 Jun 09.
Publication Year :
2022

Abstract

Background and Objectives : The objective of this study was to evaluate the effects of bisphosphonate (BP) administration on tooth growth, using CT-data of a minipig animal model investigation. Materials and Methods : Tooth growth was evaluated in minipigs, with eight animals receiving weekly zoledronate (ZOL) and three animals serving as the control group. Tooth growth was evaluated at the right 2nd molar (M2) in the maxilla. A computed tomography-based measuring method was applied to evaluate tooth growth in the coronal-apical, buccal-oral and mesial-distal axis. Results : ZOL-administration was found to impact tooth growth in all evaluated measuring axes, with the highest effect observed in the coronal-apical axis. Conclusions : Detrimental effects of BP administration on growing teeth have been reported by a number of investigators. The results of this investigation demonstrate that intravenous ZOL affects the growth of the whole tooth within a short period of administration. With BPs being administered to a growing number of pediatric patients, further studies should be conducted to qualify and quantify the effects of BPs on developing teeth.

Details

Language :
English
ISSN :
1648-9144
Volume :
58
Issue :
6
Database :
MEDLINE
Journal :
Medicina (Kaunas, Lithuania)
Publication Type :
Academic Journal
Accession number :
35744041
Full Text :
https://doi.org/10.3390/medicina58060778