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Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2022 Jun 10; Vol. 23 (12). Date of Electronic Publication: 2022 Jun 10. - Publication Year :
- 2022
-
Abstract
- The microbial community acts as an active player in maintaining homeostasis and immune functions through a continuous and changeable cross-talk with the host immune system. Emerging evidence suggests that altered microbial composition, known as dysbiosis, might perturb the delicate balance between the microbiota and the immune system, triggering inflammation and potentially contributing to the pathogenesis and development of chronic inflammatory diseases. This review will summarize the current evidence about the microbiome-immunity cross-talk, especially focusing on the microbiota alterations described in patients with rheumatic diseases and on the recent findings concerning the interaction between microbiota, metabolic function, and the immune system.
- Subjects :
- Dysbiosis
Humans
Inflammation
Connective Tissue Diseases
Microbiota
Vasculitis
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 23
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 35742974
- Full Text :
- https://doi.org/10.3390/ijms23126532