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Characterization of Virologic Rebound Following Nirmatrelvir-Ritonavir Treatment for Coronavirus Disease 2019 (COVID-19).

Characterization of Virologic Rebound Following Nirmatrelvir-Ritonavir Treatment for Coronavirus Disease 2019 (COVID-19).

Authors :
Boucau J
Uddin R
Marino C
Regan J
Flynn JP
Choudhary MC
Chen G
Stuckwisch AM
Mathews J
Liew MY
Singh A
Reynolds Z
Iyer SL
Chamberlin GC
Vyas TD
Vyas JM
Turbett SE
Li JZ
Lemieux JE
Barczak AK
Siedner MJ
Source :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2023 Feb 08; Vol. 76 (3), pp. e526-e529.
Publication Year :
2023

Abstract

We enrolled 7 individuals with recurrent symptoms or antigen test conversion following nirmatrelvir-ritonavir treatment. High viral loads (median 6.1 log10 copies/mL) were detected after rebound for a median of 17 days after initial diagnosis. Three had culturable virus for up to 16 days after initial diagnosis. No known resistance-associated mutations were identified.<br />Competing Interests: Potential conflicts of interest. J. E. L. reports grant to institution from the Centers for Disease Control and Prevention (CDC) outside of the submitted work; consulting fees from Sherlock Biosciences paid to individual; and honoraria paid to individual from Emerson Hospital and Virology Education. S. E. T. reports grants or contracts from the CDC for COVID-related work paid to the institution outside of the submitted work and travel support from the Duke Clinical Research Institute paid to self. All other authors report no conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.<br /> (© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Details

Language :
English
ISSN :
1537-6591
Volume :
76
Issue :
3
Database :
MEDLINE
Journal :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Publication Type :
Academic Journal
Accession number :
35737946
Full Text :
https://doi.org/10.1093/cid/ciac512