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Characterization of Virologic Rebound Following Nirmatrelvir-Ritonavir Treatment for Coronavirus Disease 2019 (COVID-19).
Characterization of Virologic Rebound Following Nirmatrelvir-Ritonavir Treatment for Coronavirus Disease 2019 (COVID-19).
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2023 Feb 08; Vol. 76 (3), pp. e526-e529. - Publication Year :
- 2023
-
Abstract
- We enrolled 7 individuals with recurrent symptoms or antigen test conversion following nirmatrelvir-ritonavir treatment. High viral loads (median 6.1 log10 copies/mL) were detected after rebound for a median of 17 days after initial diagnosis. Three had culturable virus for up to 16 days after initial diagnosis. No known resistance-associated mutations were identified.<br />Competing Interests: Potential conflicts of interest. J. E. L. reports grant to institution from the Centers for Disease Control and Prevention (CDC) outside of the submitted work; consulting fees from Sherlock Biosciences paid to individual; and honoraria paid to individual from Emerson Hospital and Virology Education. S. E. T. reports grants or contracts from the CDC for COVID-related work paid to the institution outside of the submitted work and travel support from the Duke Clinical Research Institute paid to self. All other authors report no conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.<br /> (© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Humans
COVID-19 Drug Treatment
Ritonavir therapeutic use
Mutation
COVID-19
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6591
- Volume :
- 76
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 35737946
- Full Text :
- https://doi.org/10.1093/cid/ciac512