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Can mesenchymal stem cells derived from adipose tissue and their conditioned medium improve ovarian functions? A mini-review.

Authors :
Pouryousefi-Koodehi T
Shayegan S
Hashemi S
Arefnezhad R
Roghani-Shahraki H
Motedayyen H
Taghizabet N
Rezaei-Tazangi F
Source :
Zygote (Cambridge, England) [Zygote] 2022 Oct; Vol. 30 (5), pp. 589-592. Date of Electronic Publication: 2022 Jun 22.
Publication Year :
2022

Abstract

Stable ovarian function is a key factor in the performance of the reproductive system. In contrast, some ovarian function-related diseases, such as polycystic ovarian syndrome, premature ovarian failure (POF), and ovarian cancer, are the main cause of infertility and death of women around the world. Despite multiple attempts, there are no effective tools against these conditions; however, mesenchymal stem cell-based therapy, especially using adipose tissue, has attracted much attention in medicine in light of its advantages such as easy isolation and accessibility. Conversely, it has been suggested that MSC-conditioned medium (CM) can restore injured tissues and has high immunocompatibility. So, here, we will summarize the effects of administration of MSCs and CM derived from adipose tissue on ovarian functions and related diseases.

Details

Language :
English
ISSN :
1469-8730
Volume :
30
Issue :
5
Database :
MEDLINE
Journal :
Zygote (Cambridge, England)
Publication Type :
Academic Journal
Accession number :
35730554
Full Text :
https://doi.org/10.1017/S0967199422000235