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Vanillin crosslinked chitosan films: The states of water and the effect of carriers on curcumin uptake.

Authors :
da Silva RLCG
Bernardinelli OD
Frachini ECG
Ulrich H
Sabadini E
Petri DFS
Source :
Carbohydrate polymers [Carbohydr Polym] 2022 Sep 15; Vol. 292, pp. 119725. Date of Electronic Publication: 2022 Jun 11.
Publication Year :
2022

Abstract

In this work, chitosan chains were crosslinked with different contents of vanillin (Van), characterized and loaded with curcumin (CUR), a hydrophobic drug. Sodium dodecyl sulfate (SDS), Tween 20® (T20) and β-cyclodextrin (βCD) were used as curcumin carriers. Films prepared with Van 20 % yielded gel content of 70 %, swelling degree of ~23 g <subscript>water</subscript> /g, bound water and capillary water, as revealed by Time-Domain Nuclear Magnetic Resonance measurements. Films prepared with higher Van contents showed small swelling degree (< 1.6 g <subscript>water</subscript> /g) and hydrophobicity, making them inadequate for drug loading. UV-Vis and fluorescence spectroscopic studies indicated that Van 20 % combined with SDS and SDS/βCD presented the highest CUR uptake (~3.0 mg/g), favored by electrostatic interactions and hydrophobic interactions. CHI and Van 20 % films did not present any cytotoxicity in human neuroblastoma SH-SY5Y cells. At pH 1.0 the films were completely soluble, pointing to their potential application as gastric delivery systems for hydrophobic drugs. Chemical compounds studied in the manuscript: Chitosan, vanillin, curcumin, β-cyclodextrin, sodium dodecyl sulfate, polyethylene glycol sorbitan monolaurate.<br /> (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-1344
Volume :
292
Database :
MEDLINE
Journal :
Carbohydrate polymers
Publication Type :
Academic Journal
Accession number :
35725193
Full Text :
https://doi.org/10.1016/j.carbpol.2022.119725