Haematopoiesis in Zebrafish (Danio Rerio).

Authors :: Stosik M
Tokarz-Deptuła B
Deptuła W
Source :: Frontiers in immunology [Front Immunol] 2022 Jun 02; Vol. 13, pp. 902941. Date of Electronic Publication: 2022 Jun 02 (Print Publication: 2022).
Publication Year :: 2022
Abstract: Haematopoiesis in fish and mammals is a complex process, and many aspects regarding its model and the differentiation of haematopoietic stem cells (HSCs) still remain enigmatic despite advanced studies. The effects of microenvironmental factors or HSCs niche and signalling pathways on haematopoiesis are also unclear. This review presents Danio rerio as a model organism for studies on haematopoiesis in vertebrates and discusses the development of this process during the embryonic period and in adult fish. It describes the role of the microenvironment of the haematopoietic process in regulating the formation and function of HSCs/HSPCs (hematopoietic stem/progenitor cells) and highlights facts and research areas important for haematopoiesis in fish and mammals.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Stosik, Tokarz-Deptuła and Deptuła.)