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Histological quantification of cerebral cavernous malformations in the murine brain.
- Source :
-
STAR protocols [STAR Protoc] 2022 Jun 09; Vol. 3 (2), pp. 101448. Date of Electronic Publication: 2022 Jun 09 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- In the study of cerebral cavernous malformations (CCMs), the quantification of lesion burden is the main parameter for evaluation of disease severity and efficacy of drugs. We describe a reliable and cost-effective protocol to evaluate the number and the size of vascular malformations in the murine brain. This approach is based on histology and confocal imaging and can be performed with standard laboratory equipment. We detail the preparation of brain sections followed by image acquisition and analysis. For complete details on the use and execution of this protocol, please refer to Maderna et al. (2022).<br />Competing Interests: The authors declare no competing interests.<br /> (© 2022 The Author(s).)
Details
- Language :
- English
- ISSN :
- 2666-1667
- Volume :
- 3
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- STAR protocols
- Publication Type :
- Academic Journal
- Accession number :
- 35712011
- Full Text :
- https://doi.org/10.1016/j.xpro.2022.101448