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Paraganglioma of the urinary bladder initially diagnosed as gastrointestinal stromal tumor requiring combined resection of the rectum: a case report.
- Source :
-
World journal of surgical oncology [World J Surg Oncol] 2022 Jun 08; Vol. 20 (1), pp. 185. Date of Electronic Publication: 2022 Jun 08. - Publication Year :
- 2022
-
Abstract
- Background: Paraganglioma of the urinary bladder (Pub) is rare and presents with clinical symptoms caused by catecholamine production and release. The typical symptoms of Pub are hypertension, macroscopic hematuria, and a hypertensive crisis during micturition. The average size of detected Pubs is approximately 3 cm. Herein, we report a case of a large Pub in which the symptoms were masked by oral medication, precise preoperative diagnosis was difficult, and intraoperative confirmation of tumoral adhesion to the rectum resulted in hypertensive attacks during surgery.<br />Case Presentation: A 64-year-old Japanese male with a history of hypertension and arrhythmia controlled with oral medication presented with a large tumor in the pelvic region, detected on examination for weight loss, with no clinical symptoms. Computed tomography and magnetic resonance imaging revealed a tumor measuring 77 mm in diameter in the posterior wall of the urinary bladder. The border with the rectum was unclear, and the tumor showed heterogeneous enhancement in the solid part with an enhancing hypodense lesion. Cystoscopy revealed compression of the bladder trigone by external masses; however, no tumor was visible in the lumen. Endoscopic ultrasonography-guided fine-needle aspiration revealed CD34-positive spindle-shaped cells in the fibrous tissue, suggestive of a mesenchymal neoplasm. The tumor was suspected to be a gastrointestinal stromal tumor, and surgery was performed. After laparotomy, we suspected that the tumor had invaded the rectum, and total cystectomy and anterior resection of the rectum were performed. Histologically, the tumor cells had granular or clear amphophilic cytoplasm with an oval nucleus and nests of cells delimited by connective tissue and vascular septations. Immunohistochemically, the tumor was positive for chromogranin A, CD56, and synaptophysin, and a diagnosis of paraganglioma of the urinary bladder was confirmed. There was no tumor recurrence at the 7-month follow-up.<br />Conclusion: This case highlights the importance of careful examination of pelvic tumors, including endocrine testing, for detecting paraganglioma of the urinary bladder in patients with a history of hypertension or arrhythmia.<br /> (© 2022. The Author(s).)
- Subjects :
- Humans
Male
Middle Aged
Pelvis pathology
Rectum pathology
Urinary Bladder pathology
Adrenal Gland Neoplasms
Gastrointestinal Stromal Tumors diagnosis
Gastrointestinal Stromal Tumors surgery
Hypertension
Paraganglioma diagnosis
Paraganglioma pathology
Paraganglioma surgery
Pheochromocytoma
Urinary Bladder Neoplasms diagnosis
Urinary Bladder Neoplasms pathology
Urinary Bladder Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1477-7819
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- World journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 35676716
- Full Text :
- https://doi.org/10.1186/s12957-022-02662-7