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Associations of Genome-Wide Polygenic Risk Score and Risk Factors With Hypertension in a Japanese Population.

Authors :
Fujii R
Hishida A
Nakatochi M
Tsuboi Y
Suzuki K
Kondo T
Ikezaki H
Hara M
Okada R
Tamura T
Shimoshikiryo I
Suzuki S
Koyama T
Kuriki K
Takashima N
Arisawa K
Momozawa Y
Kubo M
Takeuchi K
Wakai K
Source :
Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2022 Aug; Vol. 15 (4), pp. e003612. Date of Electronic Publication: 2022 Jun 06.
Publication Year :
2022

Abstract

Background: Although many polygenic risk scores (PRS) for cardiovascular traits have been developed in European populations, it is an urgent task to construct a PRS and to evaluate its ability in non-European populations. We developed a genome-wide PRS for blood pressure in a Japanese population and examined the associations between this PRS and hypertension prevalence.<br />Methods: We performed a cross-sectional study in 11 252 Japanese individuals who participated in the J-MICC (Japan Multi-Institutional Collaborative Cohort) study. Using publicly available GWAS summary statistics from Biobank Japan, we developed the PRS in the target data (n=7876). With >30 000 single nucleotide polymorphisms, we evaluated PRS performance in the test data (n=3376). Hypertension was defined as systolic blood pressure of 130 mm Hg or more, or diastolic blood pressure of 85 mm Hg or more, or taking an antihypertensive drug.<br />Results: Compared with the middle PRS quintile, the prevalence of hypertension at the top PRS quintile was higher independently from traditional risk factors (odds ratio, 1.73 [95% CI, 1.32-2.27]). The difference of mean systolic blood pressure and diastolic blood pressure between the middle and the top PRS quintile was 4.55 (95% CI, 2.26-6.85) and 2.32 (95% CI, 0.86-3.78) mm Hg, respectively. Subgroups reflecting combinations of Japanese PRS and modifiable lifestyles and factors (smoking, alcohol intake, sedentary time, and obesity) were associated with the prevalence of hypertension. A European-derived PRS was not associated with hypertension in our participants.<br />Conclusions: A PRS for blood pressure was significantly associated with hypertension and BP traits in a general Japanese population. Our findings also highlighted the importance of a combination of PRS and risk factors for identifying high-risk subgroups.

Details

Language :
English
ISSN :
2574-8300
Volume :
15
Issue :
4
Database :
MEDLINE
Journal :
Circulation. Genomic and precision medicine
Publication Type :
Academic Journal
Accession number :
35666837
Full Text :
https://doi.org/10.1161/CIRCGEN.121.003612