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miRNA-432 and SLC38A1 as Predictors of Hepatocellular Carcinoma Complicated with Alcoholic Steatohepatitis.
- Source :
-
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2022 May 25; Vol. 2022, pp. 4832611. Date of Electronic Publication: 2022 May 25 (Print Publication: 2022). - Publication Year :
- 2022
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Abstract
- Alcoholic steatohepatitis (ASH) is asymptomatic in the early stages and is typically advanced at the time of diagnosis. With the global rise in alcohol abuse, ASH is currently among the most detrimental diseases around the world. Hepatocellular carcinoma (HCC) is one of the final outcomes of numerous liver diseases. However, at present, HCC screening is mostly focused on liver cancer development. Moreover, there is no effective biomarker to predict the prognosis and recurrence of liver cancer. Meanwhile, there are limited studies on the prognosis and recurrence of HCC patients complicated with ASH. In this study, using bioinformatic analysis as well as cellular and animal models, we screened the differentially expressed (DE) miRNA-432 and SLC38A1 gene in ASH. Based on our analysis, miRNA-432 targeted SLC38A1, and the levels of miRNA-432 and SLC38A1 could accurately predict the overall survival (OS) and relapse free survival (RFS) in patients with liver cancer. Hence, these two genetic elements have the potential to synergistically predict the prognosis and recurrence of HCC complicated with ASH.<br />Competing Interests: The authors declare that they have no competing interests.<br /> (Copyright © 2022 Chao Cai et al.)
- Subjects :
- Amino Acid Transport System A
Humans
Neoplasm Recurrence, Local
Carcinoma, Hepatocellular complications
Carcinoma, Hepatocellular genetics
Fatty Liver, Alcoholic complications
Fatty Liver, Alcoholic genetics
Liver Neoplasms complications
Liver Neoplasms diagnosis
Liver Neoplasms genetics
MicroRNAs genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1942-0994
- Volume :
- 2022
- Database :
- MEDLINE
- Journal :
- Oxidative medicine and cellular longevity
- Publication Type :
- Academic Journal
- Accession number :
- 35663198
- Full Text :
- https://doi.org/10.1155/2022/4832611