Back to Search
Start Over
Quantitative assessment of regional lung ventilation in emphysematous mice using hyperpolarized 129 Xe MRI with a continuous flow hyperpolarizing system.
- Source :
-
Magnetic resonance imaging [Magn Reson Imaging] 2022 Oct; Vol. 92, pp. 88-95. Date of Electronic Publication: 2022 May 30. - Publication Year :
- 2022
-
Abstract
- Background: Lung ventilation function in small animals can be assessed by using hyperpolarized gas MRI. For these experiments a free breathing protocol is generally preferred to mechanical ventilation as mechanical ventilation can often lead to ventilation lung injury, while the need to maintain a gas reservoir may lead to a partial reduction of the polarization.<br />Purpose: To evaluate regional lung ventilation of mice by a simple but fast method under free breathing and give evidence for effectiveness with an elastase instilled emphysematous mice.<br />Animal Model: Emphysematous mice.<br />Materials and Methods: A Look-Locker based saturation recovery sequence was developed for continuous flow hyperpolarized (CF-HP) <superscript>129</superscript> Xe gas experiments, and the apparent gas-exchange rate, k', was measured by the analysis of the saturation recovery curve.<br />Results: In mice with elastase-induced mild emphysema, reductions of 15-30% in k' values were observed as the results of lesion-induced changes in the lung.<br />Data Conclusion: The proposed method was applied to an emphysematous model mice and ventilation dysfunctions have been approved as a definite decrease in k' values, supporting the usefulness for a non-invasive assessment of the lung functions in preclinical study by the CF-HP <superscript>129</superscript> Xe experiments.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-5894
- Volume :
- 92
- Database :
- MEDLINE
- Journal :
- Magnetic resonance imaging
- Publication Type :
- Academic Journal
- Accession number :
- 35654279
- Full Text :
- https://doi.org/10.1016/j.mri.2022.05.017