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An observation study of urinary biomarker exploratory in Alzheimer's disease using high-resolution mass spectrometry.
- Source :
-
Biomedical chromatography : BMC [Biomed Chromatogr] 2022 Sep; Vol. 36 (9), pp. e5421. Date of Electronic Publication: 2022 Jun 09. - Publication Year :
- 2022
-
Abstract
- Alzheimer's disease (AD) is regarded as a progressive neurodegenerative dementia, characterized by degeneration of distinct neuronal populations. A case-control study was carried out using high-resolution mass spectrometry to explore AD-associated urinary metabolic biomarkers from 30 AD patients and 30 cognitively normal (CN) individuals. In total, 49 metabolites were determined and validated as known compounds using LC/MS analysis. Using the two-sample t-test statistical analysis (Pā<ā0.05), 19 metabolites were shown to be significantly different from AD to CN. A diagnostic model of the receiver operating characteristic curve was constructed with a combination of nine molecules out of 19 metabolites, it yielded a separation with an area under the curve value of 0.976 between the two groups. This study indicated that urinary metabolites showed a significant expression between AD and CN. AD-related metabolites enable to satisfy the diagnostic power of disease discrimination. In addition, as a noninvasive approach, urine collection is done easily in clinical diagnosis of AD.<br /> (© 2022 John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1099-0801
- Volume :
- 36
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Biomedical chromatography : BMC
- Publication Type :
- Academic Journal
- Accession number :
- 35653409
- Full Text :
- https://doi.org/10.1002/bmc.5421