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Non-Coding RNA in Penile Cancer.

Authors :: Pinho JD
Silva GEB
Teixeira-Júnior AAL
Rocha TMS
Batista LL
de Sousa AM
Calixto JRR
Burbano RR
de Souza CRT
Khayat AS
Source :: Frontiers in oncology [Front Oncol] 2022 May 13; Vol. 12, pp. 812008. Date of Electronic Publication: 2022 May 13 (Print Publication: 2022).
Publication Year :: 2022
Abstract: Penile cancer (PC) still presents a health threat for developing countries, in particular Brazil. Despite this, little progress has been made on the study of markers, including molecular ones, that can aid in the correct management of the patient, especially concerning lymphadenectomy. As in other neoplasms, non-coding RNAs (ncRNAs) have been investigated for penile cancer, with emphasis on microRNAs, piRNAs (PIWI-interacting small RNAs), and long non-coding RNAs (LncRNAs). In this context, this review aims to assemble the available knowledge on non-coding RNA linked in PC, contributing to our understanding of the penile carcinogenesis process and addressing their clinical relevance. ncRNAs are part of the novel generation of biomarkers, with high potential for diagnosis and prognosis, orientating the type of treatment. Furthermore, its versatility regarding the use of paraffin samples makes it possible to carry out retrospective studies.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Pinho, Silva, Teixeira-Júnior, Rocha, Batista, de Sousa, Calixto, Burbano, Souza and Khayat.)