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Avoiding Toxicity With Lung Radiation Therapy: An IASLC Perspective.
- Source :
-
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2022 Aug; Vol. 17 (8), pp. 961-973. Date of Electronic Publication: 2022 May 29. - Publication Year :
- 2022
-
Abstract
- Toxicity concerns from thoracic radiation therapy in the treatment of lung cancers have changed substantially over the past few decades. Survival in the treatment of lung cancer has markedly improved and the introduction of advanced radiation and imaging techniques to treatment planning and delivery has made reducing toxicity possible. Phase 3 dose-escalation trials have revealed that excess dose to critical organs within the thorax can negatively impact overall survival. We summarize the existing literature on the known toxicities of thoracic radiation therapy, summarize the technological advances that have made toxicity reduction possible, and provide an overview of emerging technologies and biomarkers that are being evaluated to assess future toxicity reductions.<br /> (Crown Copyright © 2022. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Lung
Carcinoma, Non-Small-Cell Lung drug therapy
Lung Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1556-1380
- Volume :
- 17
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 35649502
- Full Text :
- https://doi.org/10.1016/j.jtho.2022.05.003