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CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection.
- Source :
-
Cell reports [Cell Rep] 2022 May 31; Vol. 39 (9), pp. 110896. - Publication Year :
- 2022
-
Abstract
- HIV/Mycobacterium tuberculosis (Mtb) co-infected individuals have an increased risk of tuberculosis prior to loss of peripheral CD4 T cells, raising the possibility that HIV co-infection leads to CD4 T cell depletion in lung tissue before it is evident in blood. Here, we use rhesus macaques to study the early effects of simian immunodeficiency virus (SIV) co-infection on pulmonary granulomas. Two weeks after SIV inoculation of Mtb-infected macaques, Mtb-specific CD4 T cells are dramatically depleted from granulomas, before CD4 T cell loss in blood, airways, and lymph nodes, or increases in bacterial loads or radiographic evidence of disease. Spatially, CD4 T cells are preferentially depleted from the granuloma core and cuff relative to B cell-rich regions. Moreover, live imaging of granuloma explants show that intralesional CD4 T cell motility is reduced after SIV co-infection. Thus, granuloma CD4 T cells may be decimated before many co-infected individuals experience the first symptoms of acute HIV infection.<br />Competing Interests: Declaration of interests The contents of this publication do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the United States government. The authors declare no competing interests.<br /> (Published by Elsevier Inc.)
- Subjects :
- Animals
CD4-Positive T-Lymphocytes
Granuloma pathology
Macaca mulatta
Coinfection pathology
HIV Infections complications
HIV Infections pathology
Simian Acquired Immunodeficiency Syndrome complications
Simian Acquired Immunodeficiency Syndrome pathology
Simian Immunodeficiency Virus
Tuberculosis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2211-1247
- Volume :
- 39
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Cell reports
- Publication Type :
- Academic Journal
- Accession number :
- 35649361
- Full Text :
- https://doi.org/10.1016/j.celrep.2022.110896