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Durable Surfaces from Film-Forming Silver Assemblies for Long-Term Zero Bacterial Adhesion without Toxicity.
- Source :
-
ACS central science [ACS Cent Sci] 2022 May 25; Vol. 8 (5), pp. 546-561. Date of Electronic Publication: 2022 Apr 27. - Publication Year :
- 2022
-
Abstract
- The long-term prevention of biofilm formation on the surface of indwelling medical devices remains a challenge. Silver has been reutilized in recent years for combating biofilm formation due to its indisputable bactericidal potency; however, the toxicity, low stability, and short-term activity of the current silver coatings have limited their use. Here, we report the development of silver-based film-forming antibacterial engineered (SAFE) assemblies for the generation of durable lubricous antibiofilm surface long-term activity without silver toxicity that was applicable to diverse materials via a highly scalable dip/spray/solution-skinning process. The SAFE coating was obtained through a large-scale screening, resulting in effective incorporation of silver nanoparticles (∼10 nm) into a stable nonsticky coating with high surface hierarchy and coverage, which guaranteed sustained silver release. The lead coating showed zero bacterial adhesion over a 1 month experiment in the presence of a high load of diverse bacteria, including difficult-to-kill and stone-forming strains. The SAFE coating showed high biocompatibility and excellent antibiofilm activity in vivo .<br />Competing Interests: The authors declare the following competing financial interest(s): The University of British Columbia has filed for patent protection on the technology described here. H.Y.-A., K.Y., D.L., and J.N.K. are named as inventors on a PCT patent application submitted. The rest of the authors declare no competing interests.<br /> (© 2022 The Authors. Published by American Chemical Society.)
Details
- Language :
- English
- ISSN :
- 2374-7943
- Volume :
- 8
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- ACS central science
- Publication Type :
- Academic Journal
- Accession number :
- 35647287
- Full Text :
- https://doi.org/10.1021/acscentsci.1c01556