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An Overview of Off-Label Use of Humanized Monoclonal Antibodies in Paediatrics.
- Source :
-
Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2022 Apr 29; Vol. 58 (5). Date of Electronic Publication: 2022 Apr 29. - Publication Year :
- 2022
-
Abstract
- In recent years, off-label and unlicensed drug use has extensively developed in the paediatric population. For a long time, clinical trials in the paediatric population were considered complicated to perform because of ethical problems, causing frequent off-label use. Off-label drug use remains an important public health issue, especially for children with rare conditions or with diseases not responsive to conventional treatments. The present paper is a narrative review of the literature of off-label drug use in children. The aim of our study is to summarize the main works dealing with the off-label use of biological drugs in paediatrics. Further studies analyzing their efficacy, safety, and cost-benefit ratios are needed to extend the use of biological therapies to the paediatric population.
Details
- Language :
- English
- ISSN :
- 1648-9144
- Volume :
- 58
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Medicina (Kaunas, Lithuania)
- Publication Type :
- Academic Journal
- Accession number :
- 35630042
- Full Text :
- https://doi.org/10.3390/medicina58050625