Back to Search Start Over

Effect of Ziziphus jujube on cardiometabolic factors and systemic inflammation in type 2 diabetic patients: A randomized controlled trial.

Authors :
Farhadnejad H
Asghari G
Hedayati M
Sahranavard S
Teymoori F
Mirmiran P
Azizi F
Source :
Clinical nutrition ESPEN [Clin Nutr ESPEN] 2022 Jun; Vol. 49, pp. 53-60. Date of Electronic Publication: 2022 Apr 14.
Publication Year :
2022

Abstract

Background & Aims: In the current study, we aimed to assess the effect of dried Ziziphus jujube on blood glucose, lipid profiles, anthropometric indices, and inflammatory factors in type 2 diabetic(T2D) patients.<br />Methods: In this randomized controlled clinical trial, 48 patients, aged 30-65 years, were randomly assigned to two intervention(n = 24) and control(n = 24) groups. The subjects in the intervention group received 30 g Ziziphus jujube daily for 12 weeks. At baseline and the end of the 12th week, 10 ml of blood was taken from each patient after a 12- to 14-h overnight fasting. Plasma levels of fasting plasma glucose (FPG), triglycerides(TGs), total cholesterol(TC), high-density lipoprotein-cholesterol(HDL-C), low-density lipoprotein-cholesterol(LDL-C), high-sensitivity C-reactive protein(hs-CRP), and interleukin-6(IL-6) were measured. Anthropometric indices were determined.<br />Results: Plasma FPG, TG, TC, and LDL-C decreased significantly up to -11.36%, -13.59%, -7.46%, -7.65% in the Ziziphus jujube group at the end of week 12 compared to baseline, respectively (P < 0.05), and this reduction was significant in comparison with the control group (P < 0.05). The plasma hs-CRP reduced significantly up to -24.46% in the Ziziphus jujube group at the end of week 12 compared to baseline (P < 0.05), however, this reduction was not significant in comparison with the control group (P < 0.05). Also, there were no significant differences between the two groups in mean changes of body mass index, plasma HDL-C, and IL-6.<br />Conclusions: The current study showed that daily consumption of Ziziphus jujube may have beneficial effects on the lipid profiles and blood glucose levels in T2D.<br />Clinical Trial Registration Number: T his clinical trial was registered at the Iranian registry of clinical trials (IRCT registration number: IRCT20181210041913N1).<br />Competing Interests: Declaration of Competing Interest The authors declared there is no conflict of interest.<br /> (Copyright © 2022 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
2405-4577
Volume :
49
Database :
MEDLINE
Journal :
Clinical nutrition ESPEN
Publication Type :
Academic Journal
Accession number :
35623863
Full Text :
https://doi.org/10.1016/j.clnesp.2022.03.043