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The Relationship Between Vitamin D and Postoperative Atrial Fibrillation: A Prospective Cohort Study.

Authors :
Ohlrogge AH
Brederecke J
Ojeda FM
Pecha S
Börschel CS
Conradi L
Rimkus V
Blankenberg S
Zeller T
Schnabel RB
Source :
Frontiers in nutrition [Front Nutr] 2022 May 10; Vol. 9, pp. 851005. Date of Electronic Publication: 2022 May 10 (Print Publication: 2022).
Publication Year :
2022

Abstract

Background and Aims: The relationship between postoperative atrial fibrillation (POAF) and 25-hydroxyvitamin D [25(OH)D] concentration as well as vitamin D supplementation has been discussed controversially. The relation of pre-operative vitamin D status and POAF remains unclear.<br />Methods and Results: We analysed the risk of POAF in a prospective, observational cohort study of n = 201 patients undergoing coronary artery bypass graft surgery (CABG) with 25(OH)D concentration. The median age was 66.6 years, 15.4% were women. The median (25th/75th percentile) vitamin D concentration at baseline was 17.7 (12.6/23.7) ng/ml. During follow-up we observed 48 cases of POAF. In age, sex, and creatinine-adjusted analyses, 25(OH)D was associated with an increased risk of POAF, though with borderline statistical significance [odds ratio (OR) 1.85, 95% confidence interval (CI) 0.87-3.92, p-value 0.107], in further risk factor-adjusted analyses the results remained stable (OR 1.99, 95% CI 0.90-4.39, p-value 0.087). The subgroup with vitamin D supplementation at baseline showed an increased risk of POAF (OR 5.03, 95% CI 1.13-22.33, p-value 0.034).<br />Conclusion: In our contemporary mid-European cohort, higher 25(OH)D concentration did not show a benefit for POAF in CABG patients and may even be harmful, though with borderline statistical significance. Our data are in line with a recent randomised study in community-based adults and call for further research to determine both, the clinical impact of elevated 25(OH)D concentration and vitamin D supplementation as well as the possible underlying pathophysiological mechanisms.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2022 Ohlrogge, Brederecke, Ojeda, Pecha, Börschel, Conradi, Rimkus, Blankenberg, Zeller and Schnabel.)

Details

Language :
English
ISSN :
2296-861X
Volume :
9
Database :
MEDLINE
Journal :
Frontiers in nutrition
Publication Type :
Academic Journal
Accession number :
35619954
Full Text :
https://doi.org/10.3389/fnut.2022.851005