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The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation.
- Source :
-
Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2022 Dec; Vol. 42 (12), pp. 1615-1621. Date of Electronic Publication: 2022 May 26. - Publication Year :
- 2022
-
Abstract
- Objective: Assess if maternal betamethasone administration at 34-35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation.<br />Study Design: Nested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 34 <superscript>0</superscript> -35 <superscript>6</superscript> weeks gestation before 72 h (aEEG 1) and at 5-7 days (aEEG 2) if hospitalized. Personnel and aEEG central readers were masked to the intervention. The primary outcome was maturation reflected by cycle frequency; secondary outcomes were border voltage, span, and discontinuity.<br />Results: 58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had a greater lower border voltage and a broader span. On aEEG 2, both groups displayed increases in lower border voltage.<br />Conclusions: Betamethasone associated changes in lower border voltage support accelerated electrical activity. Further investigation is needed to understand the broader span.<br /> (© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Details
- Language :
- English
- ISSN :
- 1476-5543
- Volume :
- 42
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of perinatology : official journal of the California Perinatal Association
- Publication Type :
- Academic Journal
- Accession number :
- 35618748
- Full Text :
- https://doi.org/10.1038/s41372-022-01415-4