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The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation.

Authors :
Laptook AR
Chalak L
Pappas A
Davis A
Sanchez PJ
Van Meurs KP
Oh W
Sommers R
Shankaran S
Hensman AM
Rouse DJ
McDonald S
Das A
Goldberg RN
Ambalavanan N
Gyamfi-Bannerman C
Thom EA
Higgins RD
Source :
Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2022 Dec; Vol. 42 (12), pp. 1615-1621. Date of Electronic Publication: 2022 May 26.
Publication Year :
2022

Abstract

Objective: Assess if maternal betamethasone administration at 34-35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation.<br />Study Design: Nested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 34 <superscript>0</superscript> -35 <superscript>6</superscript> weeks gestation before 72 h (aEEG 1) and at 5-7 days (aEEG 2) if hospitalized. Personnel and aEEG central readers were masked to the intervention. The primary outcome was maturation reflected by cycle frequency; secondary outcomes were border voltage, span, and discontinuity.<br />Results: 58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had a greater lower border voltage and a broader span. On aEEG 2, both groups displayed increases in lower border voltage.<br />Conclusions: Betamethasone associated changes in lower border voltage support accelerated electrical activity. Further investigation is needed to understand the broader span.<br /> (© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.)

Details

Language :
English
ISSN :
1476-5543
Volume :
42
Issue :
12
Database :
MEDLINE
Journal :
Journal of perinatology : official journal of the California Perinatal Association
Publication Type :
Academic Journal
Accession number :
35618748
Full Text :
https://doi.org/10.1038/s41372-022-01415-4