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Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 expression and its relationship with T cell activation in human immunodeficiency virus/acquired immune deficiency syndrome patients with lung-spleen deficiency syndrome pattern.
- Source :
-
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan [J Tradit Chin Med] 2022 Jun; Vol. 42 (3), pp. 451-457. - Publication Year :
- 2022
-
Abstract
- Objective: To investigate the relationship between antiviral restriction factor Sterile Alpha Motif and Histidine-Aspartic acid domain-containing protein 1 (SAMHD1) expression and T cell activation, furthermore, identifying objective indexes of lung-spleen deficiency symptom pattern.<br />Methods: We assessed the profile of T lymphocyte subsets, characteristics of SAMHD1 and human leukocyte antigen DR (HLA-DR) expression in lung-spleen deficiency patients. At the same time, people living with human immunodeficiency virus / acquired immune deficiency syndrome (HIV/AIDS) (PLWHA) without obvious clinical symptoms and healthy donors in this area were used as controls.<br />Results: Immunohematologic indexes lower CD4 count, lower CD4/CD8 ratio and higher SAMHD1 level were found in lung-spleen deficiency patients. Furthermore, we demonstrated a positive relationship between SAMHD1 and HLA-DR level as well as with interferon factor in lung-spleen deficiency syndrome and patients without obvious clinical signs and symptoms groups.<br />Conclusions: These data indicated the positive relationship between SAMHD1 and T cell activation which further elucidated the role of SAMHD1 in cellular immune response. Furthermore, combination of T lymphocyte subsets counts and SAMHD1 level may be used as clinical and biological reference basis for the differentiation and diagnosis of HIV / AIDS traditional Chinese medicine syndromes.
Details
- Language :
- English
- ISSN :
- 2589-451X
- Volume :
- 42
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
- Publication Type :
- Academic Journal
- Accession number :
- 35610016
- Full Text :
- https://doi.org/10.19852/j.cnki.jtcm.20220408.004