Propargyl Chalcones' Radical Annulation/Sulfonation Reaction: Efficient Synthesis of Benzo[ b ]oxepin-5(2 H )-one and Chromane Derivatives.

A novel and facile methodology for the synthesis of sulfonated benzo[ b ]oxepinone and chromane derivatives was reported by the reaction of propargyl chalcones with arylsulfonyl chloride via radical cascade annulation/sulfonation under laboratory conditions. Readily available propargyl chalcones, commercialized arylsulfonyl chloride, and simple reaction conditions make this six(seven)-membered oxygen-containing heterocycles' synthetic strategy more attractive and with significant application values.