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Phytochemical Engineered Bacterial Outer Membrane Vesicles for Photodynamic Effects Promoted Immunotherapy.

Authors :
Zhuang WR
Wang Y
Lei Y
Zuo L
Jiang A
Wu G
Nie W
Huang LL
Xie HY
Source :
Nano letters [Nano Lett] 2022 Jun 08; Vol. 22 (11), pp. 4491-4500. Date of Electronic Publication: 2022 May 23.
Publication Year :
2022

Abstract

Cancer vaccines are emerging as an attractive modality for tumor immunotherapy. However, their practical application is seriously impeded by the complex fabrication and unsatisfactory outcomes. Herein, we construct bacterial outer membrane vesicles (OMVs)-based in situ cancer vaccine with phytochemical features for photodynamic effects-promoted immunotherapy. By simply fusing thylakoid membranes with OMVs, bacteria-plant hybrid vesicles (BPNs) are prepared. After systemic administration, BPNs can target tumor tissues and stimulate the activation of immune cells, including dendritic cells (DCs). The photodynamic effects derived from thylakoid lead to the disruption of local tumors and then the release of tumor-associated antigens that are effectively presented by DCs, inducing remarkable tumor-specific CD8 <superscript>+</superscript> T cell responses. Moreover, BPNs can efficiently ameliorate the immunosuppressive tumor microenvironment and further boost immune responses. Therefore, both tumor development and metastasis can be efficiently prevented. This work provides a novel idea for developing a versatile membrane-based hybrid system for highly efficient tumor treatment.

Details

Language :
English
ISSN :
1530-6992
Volume :
22
Issue :
11
Database :
MEDLINE
Journal :
Nano letters
Publication Type :
Academic Journal
Accession number :
35605283
Full Text :
https://doi.org/10.1021/acs.nanolett.2c01280