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Pituitary gonadotropin response to LHRH in human pregnancy.
- Source :
-
Obstetrics and gynecology [Obstet Gynecol] 1978 Aug; Vol. 52 (2), pp. 172-5. - Publication Year :
- 1978
-
Abstract
- The effect of synthetic LHRH on serum levels of FSH, LH, and hCG was determined during early and midgestation. Eight healthy volunteers were studied during the first (8--9 weeks) and second (15--20 weeks) trimesters of pregnancy with 4 patients in each group. Serum samples, obtained before and 15, 30, 45, 90, 120, 150, and 180 minutes after an intravenous bolus of 100 microgram LHRH, were assayed for LH, FSH, and hCG by specific radioimmunoassays. Serum levels of estradiol, progesterone, and 17 alphahydroxyprogesterone were also measured in samples obtained prior to and 3 hours after LHRH injection. The serum levels of LH and FSH were undetectable in all samples, and no increase was observed after administration of LHRH. Levels of chorionic gonadadotropin, estradiol, progesterone, and 17alpha-hydroxyprogesterone did show slight fluctuations, but there was no significant effect from LHRH administration. These results support the concept that pituitary gonadotropic function is markedly suppressed during early human pregnancy.
- Subjects :
- Adolescent
Adult
Chorionic Gonadotropin blood
Chorionic Gonadotropin physiology
Estradiol blood
Female
Follicle Stimulating Hormone blood
Humans
Hydroxyprogesterones blood
Luteinizing Hormone blood
Pregnancy Trimester, First
Pregnancy Trimester, Second
Progesterone blood
Follicle Stimulating Hormone physiology
Gonadotropin-Releasing Hormone
Luteinizing Hormone physiology
Pregnancy
Subjects
Details
- Language :
- English
- ISSN :
- 0029-7844
- Volume :
- 52
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 355962