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Lead-OR: A multimodal platform for deep brain stimulation surgery.

Lead-OR: A multimodal platform for deep brain stimulation surgery.

Authors :
Oxenford S
Roediger J
Neudorfer C
Milosevic L
Güttler C
Spindler P
Vajkoczy P
Neumann WJ
Kühn A
Horn A
Source :
ELife [Elife] 2022 May 20; Vol. 11. Date of Electronic Publication: 2022 May 20.
Publication Year :
2022

Abstract

Background: Deep brain stimulation (DBS) electrode implant trajectories are stereotactically defined using preoperative neuroimaging. To validate the correct trajectory, microelectrode recordings (MERs) or local field potential recordings can be used to extend neuroanatomical information (defined by MRI) with neurophysiological activity patterns recorded from micro- and macroelectrodes probing the surgical target site. Currently, these two sources of information (imaging vs. electrophysiology) are analyzed separately, while means to fuse both data streams have not been introduced.<br />Methods: Here, we present a tool that integrates resources from stereotactic planning, neuroimaging, MER, and high-resolution atlas data to create a real-time visualization of the implant trajectory. We validate the tool based on a retrospective cohort of DBS patients (N = 52) offline and present single-use cases of the real-time platform.<br />Results: We establish an open-source software tool for multimodal data visualization and analysis during DBS surgery. We show a general correspondence between features derived from neuroimaging and electrophysiological recordings and present examples that demonstrate the functionality of the tool.<br />Conclusions: This novel software platform for multimodal data visualization and analysis bears translational potential to improve accuracy of DBS surgery. The toolbox is made openly available and is extendable to integrate with additional software packages.<br />Funding: Deutsche Forschungsgesellschaft (410169619, 424778381), Deutsches Zentrum für Luft- und Raumfahrt (DynaSti), National Institutes of Health (2R01 MH113929), and Foundation for OCD Research (FFOR).<br />Competing Interests: SO, JR, CN, LM, CG, PS, PV, WN No competing interests declared, AK Reports personal fees from Medtronic, Boston Scientific, Abbott, Teva, Ipsen and Stadapharm, all outside the submitted work, AH Reports lecture fee for Boston Scientific outside the submitted work<br /> (© 2022, Oxenford et al.)

Details

Language :
English
ISSN :
2050-084X
Volume :
11
Database :
MEDLINE
Journal :
ELife
Publication Type :
Academic Journal
Accession number :
35594135
Full Text :
https://doi.org/10.7554/eLife.72929