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Palladium-catalyzed cross-coupling of unreactive C(sp 3 )-H bonds with azole C(sp 2 )-H bonds by using bromide as a traceless directing group.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Jun 08; Vol. 58 (46), pp. 6661-6664. Date of Electronic Publication: 2022 Jun 08. - Publication Year :
- 2022
-
Abstract
- A palladium-catalyzed intermolecular cross-coupling of unreactive C(sp <superscript>3</superscript> )-H bonds and azole C(sp <superscript>2</superscript> )-H bonds with bromide as a traceless directing group is described. The judicious selection of the bulky and electron-rich phosphine ligand is the key for the success of this cascade process. The protocol features a broad substrate scope, excellent regioselectivity, and good functional group tolerance.
- Subjects :
- Azoles
Catalysis
Ligands
Bromides
Palladium chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 58
- Issue :
- 46
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 35593262
- Full Text :
- https://doi.org/10.1039/d2cc01944b