Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma.

Authors :: Davidson SM
Schmidt DR
Heyman JE
O'Brien JP
Liu AC
Israelsen WJ
Dayton TL
Sehgal R
Bronson RT
Freinkman E
Mak HH
Fanelli GN
Malstrom S
Bellinger G
Carracedo A
Pandolfi PP
Courtney KD
Jha A
DePinho RA
Horner JW
Thomas CJ
Cantley LC
Loda M
Vander Heiden MG
Source :: Cancer research [Cancer Res] 2022 Jul 05; Vol. 82 (13), pp. 2403-2416.
Publication Year :: 2022
Abstract: Significance: Differential expression of PKM1 and PKM2 impacts prostate tumorigenesis and suggests a potential therapeutic vulnerability in prostate cancer.<br /> (©2022 The Authors; Published by the American Association for Cancer Research.)

Subjects :: Carcinogenesis
Humans
Male
Prostate metabolism
Pyruvate Kinase metabolism
Adenocarcinoma genetics
Prostatic Neoplasms genetics

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