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Imaging of hypoxia in human glioblastoma with dynamic 18F-fluoromisonidazole PET.
- Source :
-
Cancer drug resistance (Alhambra, Calif.) [Cancer Drug Resist] 2019 Mar 19; Vol. 2 (1), pp. 131-140. Date of Electronic Publication: 2019 Mar 19 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Aim: The purpose of this study was to locate the levels of hypoxia in glioblastoma PET images measured with 18F-fluoromisonidazole in human subjects. It is recognized that tumors with hypoxia are resistant to treatment by radiotherapy and chemotherapy. Methods: The images were acquired in dynamic mode for 15 min or 30 min and in static mode for two single scans at 2 h and 3 h to allow the accumulation of the radiotracer in the tumor. The images were analyzed at the voxel basis with compartmental analysis (CA) and with the usual tumor-to-blood uptake ratio (TBR). Kmeans algorithm was applied to cluster the levels of hypoxia in the images. Results: TBR at a threshold of 1.2 at imaging times of 15 min, 2 h and 3 h produced images with different clusters. Also, the comparison of TBR with the distribution volume obtained with CA had a similarity index of 0.61 ± 0.05. Conclusion: We found some differences in defining the hypoxic volume within a tumor using TBR. The compartmental analysis allowed discrimination of the tumor hypoxic sub-volumes which can be useful for a better treatment with radiotherapy.<br />Competing Interests: All authors declared that there are no conflicts of interest.<br /> (© The Author(s) 2019.)
Details
- Language :
- English
- ISSN :
- 2578-532X
- Volume :
- 2
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cancer drug resistance (Alhambra, Calif.)
- Publication Type :
- Academic Journal
- Accession number :
- 35582145
- Full Text :
- https://doi.org/10.20517/cdr.2018.21