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Capillary electrophoresis methods for impurity profiling of drugs: A review of the past decade.

Authors :
Shah M
Patel N
Tripathi N
Vyas VK
Source :
Journal of pharmaceutical analysis [J Pharm Anal] 2022 Feb; Vol. 12 (1), pp. 15-28. Date of Electronic Publication: 2021 Jul 02.
Publication Year :
2022

Abstract

Capillary electrophoresis (CE) is widely used for the impurity profiling of drugs that contain stereochemical centers in their structures, analysis of biomolecules, and characterization of biopharmaceuticals. Currently, CE is the method of choice for the analysis of foodstuffs and the determination of adulterants. This article discusses the general theory and instrumentation of CE as well as the classification of various CE techniques. It also presents an overview of research on the applications of different CE techniques in the impurity profiling of drugs in the past decade. The review briefly presents a comparison between CE and liquid chromatography methods and highlights the strengths of CE using drug compounds as examples. This review will help scientists, fellow researchers, and students to understand the applications of CE techniques in the impurity profiling of drugs.<br />Competing Interests: The authors declare that there are no conflicts of interests.<br /> (© 2021 Xi'an Jiaotong University. Production and hosting by Elsevier B.V.)

Details

Language :
English
ISSN :
2214-0883
Volume :
12
Issue :
1
Database :
MEDLINE
Journal :
Journal of pharmaceutical analysis
Publication Type :
Academic Journal
Accession number :
35573874
Full Text :
https://doi.org/10.1016/j.jpha.2021.06.009