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Update on the Use of Nanocarriers and Drug Delivery Systems and Future Directions in Cervical Cancer.

Authors :
Himiniuc LM
Toma BF
Popovici R
Grigore AM
Hamod A
Volovat C
Volovat S
Nica I
Vasincu D
Agop M
Tirnovanu M
Ochiuz L
Negura A
Grigore M
Source :
Journal of immunology research [J Immunol Res] 2022 May 04; Vol. 2022, pp. 1636908. Date of Electronic Publication: 2022 May 04 (Print Publication: 2022).
Publication Year :
2022

Abstract

Cervical cancer represents a major health problem among females due to its increased mortality rate. The conventional therapies are very aggressive and unsatisfactory when it comes to survival rate, especially in terminal stages, which requires the development of new treatment alternatives. With the use of nanotechnology, various chemotherapeutic drugs can be transported via nanocarriers directly to cervical cancerous cells, thus skipping the hepatic first-pass effect and decreasing the rate of chemotherapy side effects. This review comprises various drug delivery systems that were applied in cervical cancer, such as lipid-based nanocarriers, polymeric and dendrimeric nanoparticles, carbon-based nanoparticles, metallic nanoparticles, inorganic nanoparticles, micellar nanocarriers, and protein and polysaccharide nanoparticles. Nanoparticles have a great therapeutic potential by increasing the pharmacological activity, drug solubility, and bioavailability. Through their mechanisms, they highly increase the toxicity in the targeted cervical tumor cells or tissues by linking to specific ligands. In addition, a nondifferentiable model is proposed through holographic implementation in the dynamics of drug delivery dynamics. As any hologram functions as a deep learning process, the artificial intelligence can be proposed as a new analyzing method in cervical cancer.<br />Competing Interests: The authors declare no conflict of interests.<br /> (Copyright © 2022 Loredana Maria Himiniuc et al.)

Details

Language :
English
ISSN :
2314-7156
Volume :
2022
Database :
MEDLINE
Journal :
Journal of immunology research
Publication Type :
Academic Journal
Accession number :
35571568
Full Text :
https://doi.org/10.1155/2022/1636908