Sansoninto-induced Lung Injury.

Authors :: Komiya K
Mitsui MT
Watanabe T
Nasu M
Hiramatsu K
Kadota JI
Source :: Internal medicine (Tokyo, Japan) [Intern Med] 2022 Dec 15; Vol. 61 (24), pp. 3709-3712. Date of Electronic Publication: 2022 May 14.
Publication Year :: 2022
Abstract: A man in his 70s visited our department for dyspnea with pulmonary infiltrate that was unresolved by antibiotics. He had been taking Sansoninto for five years and doubled its dose a month ago. After discontinuing Sansoninto without any additional medications, his symptoms gradually disappeared, and pulmonary infiltration improved. Drug lymphocyte stimulation tests showed a positive result for Sansoninto. We diagnosed this patient with Sansoninto-induced lung injury. Sansoninto is a combination drug that consists of sansonin, bukuryo, senkyo, chimo, and kanzo. This paper reports the first case of Sansoninto-induced lung injury and discusses the mechanism considering its components.