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Best-worst scaling methodology to evaluate constructs of the Consolidated Framework for Implementation Research: application to the implementation of pharmacogenetic testing for antidepressant therapy.

Authors :
Salloum RG
Bishop JR
Elchynski AL
Smith DM
Rowe E
Blake KV
Limdi NA
Aquilante CL
Bates J
Beitelshees AL
Cipriani A
Duong BQ
Empey PE
Formea CM
Hicks JK
Mroz P
Oslin D
Pasternak AL
Petry N
Ramsey LB
Schlichte A
Swain SM
Ward KM
Wiisanen K
Skaar TC
Van Driest SL
Cavallari LH
Tuteja S
Source :
Implementation science communications [Implement Sci Commun] 2022 May 14; Vol. 3 (1), pp. 52. Date of Electronic Publication: 2022 May 14.
Publication Year :
2022

Abstract

Background: Despite the increased demand for pharmacogenetic (PGx) testing to guide antidepressant use, little is known about how to implement testing in clinical practice. Best-worst scaling (BWS) is a stated preferences technique for determining the relative importance of alternative scenarios and is increasingly being used as a healthcare assessment tool, with potential applications in implementation research. We conducted a BWS experiment to evaluate the relative importance of implementation factors for PGx testing to guide antidepressant use.<br />Methods: We surveyed 17 healthcare organizations that either had implemented or were in the process of implementing PGx testing for antidepressants. The survey included a BWS experiment to evaluate the relative importance of Consolidated Framework for Implementation Research (CFIR) constructs from the perspective of implementing sites.<br />Results: Participating sites varied on their PGx testing platform and methods for returning recommendations to providers and patients, but they were consistent in ranking several CFIR constructs as most important for implementation: patient needs/resources, leadership engagement, intervention knowledge/beliefs, evidence strength and quality, and identification of champions.<br />Conclusions: This study demonstrates the feasibility of using choice experiments to systematically evaluate the relative importance of implementation determinants from the perspective of implementing organizations. BWS findings can inform other organizations interested in implementing PGx testing for mental health. Further, this study demonstrates the application of BWS to PGx, the findings of which may be used by other organizations to inform implementation of PGx testing for mental health disorders.<br /> (© 2022. The Author(s).)

Details

Language :
English
ISSN :
2662-2211
Volume :
3
Issue :
1
Database :
MEDLINE
Journal :
Implementation science communications
Publication Type :
Academic Journal
Accession number :
35568931
Full Text :
https://doi.org/10.1186/s43058-022-00300-7