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Elevated LSD1 and SNAIL Expression Indicate Poor Prognosis in Hypopharynx Carcinoma.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2022 May 03; Vol. 23 (9). Date of Electronic Publication: 2022 May 03. - Publication Year :
- 2022
-
Abstract
- Head and neck squamous cell carcinomas (HNSCC) are among the most common cancers worldwide and are associated with a poor prognosis for patients. Among HNSCC, those originating in the hypopharynx have the worst prognosis. The histone demethylase LSD1 has been shown to promote cancer initiation, progression, and relapse through various mechanisms and is upregulated in many cancer tissues. LSD1 physically interacts with SNAIL and is required for SNAIL mediated transcriptional repression. Previous studies of the prognostic value of LSD1 in HNSCC have been limited in their analysis of sub-sites, and a correlation between LSD1 and SNAIL has not been shown in HNSCC patient samples. Here we used a large, representative, and clinically well-characterized cohort of 339 HNSCC patients to investigate the co-expression of LSD1 and SNAIL and their prognostic value in all HNSCC using immunohistochemical staining. Elevated LSD1 expression correlated with advanced tumor stage and poor progression-free survival (PFS) in HNSCC originating in the hypopharynx. Overexpression of the transcription factor SNAIL independently correlated with worse overall survival (OS) and PFS in HNSCC in general and prominently in tumors of the hypopharynx. Furthermore, increased LSD1 expression significantly correlated with elevated SNAIL expression in patient samples. Therefore, the presented data implicates LSD1 and SNAIL as independent prognostic biomarkers.
- Subjects :
- Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
Humans
Hypopharynx pathology
Neoplasm Recurrence, Local
Prognosis
Squamous Cell Carcinoma of Head and Neck diagnosis
Squamous Cell Carcinoma of Head and Neck genetics
Head and Neck Neoplasms diagnosis
Head and Neck Neoplasms genetics
Histone Demethylases genetics
Histone Demethylases metabolism
Hypopharyngeal Neoplasms diagnosis
Hypopharyngeal Neoplasms genetics
Snail Family Transcription Factors genetics
Snail Family Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 23
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 35563463
- Full Text :
- https://doi.org/10.3390/ijms23095075