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Investigation of rotameric conformations of substituted imidazo-[1,2- a ]pyrazine: experimental and theoretical approaches.
- Source :
-
RSC advances [RSC Adv] 2018 Mar 07; Vol. 8 (18), pp. 9707-9717. Date of Electronic Publication: 2018 Mar 07 (Print Publication: 2018). - Publication Year :
- 2018
-
Abstract
- The different rotameric conformations of imidazo-[1,2- a ]pyrazine have been synthesized and characterized by means of different experimental techniques, such as NMR, FTIR, and absorption spectroscopy and quantum chemical calculations. The different conformations were stabilized by hydrogen bonds, such as OH⋯N, ArH⋯N and ArH⋯ArH. The ground state optimizations and potential energy surface (PES) scanning profiles produced using density functional theory (DFT) show two stable rotameric forms for each molecule. The relative population of the conformations is affected by the strength of the hydrogen bonds. The calculated absorption spectra and isotopic shielding constants were acquired by time-dependent density functional theory (TD-DFT) and gauge invariant atomic orbitals (GIAO)-DFT, respectively. The strength of the hydrogen bonding interactions that resulted in the different conformations was studied by quantum theory of atoms in molecules (QTAIM).<br />Competing Interests: There are no conflicts of interest to declare.<br /> (This journal is © The Royal Society of Chemistry.)
Details
- Language :
- English
- ISSN :
- 2046-2069
- Volume :
- 8
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- RSC advances
- Publication Type :
- Academic Journal
- Accession number :
- 35540834
- Full Text :
- https://doi.org/10.1039/c7ra13617j