Synthesis of diversely substituted bis-pyrrolizidino/ thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via sequential azomethine ylide cycloaddition.

Authors :: Singh M
Hazra A
Bharitkar YP
Kalia R
Sahoo A
Saha S
Ravichandiran V
Ghosh S
Mondal NB
Source :: RSC advances [RSC Adv] 2018 May 23; Vol. 8 (34), pp. 18938-18951. Date of Electronic Publication: 2018 May 23 (Print Publication: 2018).
Publication Year :: 2018
Abstract: Curcumin has been transformed to several diversely substituted bis-pyrrolizidino/thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via a sequential azomethine ylide cycloaddition reaction using isatins/acenaphthoquinone and proline/thioproline as the reagents. The products were separated via extensive chromatography and characterized by 1D/2D NMR and HRMS analysis.<br />Competing Interests: There are no conflicts of interest to declare.<br /> (This journal is © The Royal Society of Chemistry.)

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