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Keap 1: The new Janus word on the block.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Sep 01; Vol. 71, pp. 128766. Date of Electronic Publication: 2022 May 07. - Publication Year :
- 2022
-
Abstract
- Here we draw insights from the latest serendipitous findings made on the opposing roles of a proposed drug-target protein Keap1. We weigh up how natural reactive electrophiles and electrophilic small-molecule drugs in clinical use directly impinge on seemingly conflicting, yet both Keap1-electrophile-modification-dependent, cell-survival- vs. cell-death-promoting behaviors. In the process, we convey how understanding reactive chemical-signal regulation at the single-protein-specific level is an enabling necessity in deconstructing otherwise intricate reactive-small-molecule-responsive cellular pathways. We hope this opinion piece further spurs the broader interests of basic and pharmaceutical research communities toward better understanding of molecular mechanisms underpinning reactive small-molecule-regulated signaling subsystems.<br /> (Copyright © 2022. Published by Elsevier Ltd.)
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 71
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 35537607
- Full Text :
- https://doi.org/10.1016/j.bmcl.2022.128766