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Assessment of kidney involvement in systemic sclerosis: From scleroderma renal crisis to subclinical renal vasculopathy.
- Source :
-
The American journal of the medical sciences [Am J Med Sci] 2022 Nov; Vol. 364 (5), pp. 529-537. Date of Electronic Publication: 2022 May 09. - Publication Year :
- 2022
-
Abstract
- The spectrum of kidney involvement in systemic sclerosis (SSc) includes scleroderma renal crisis, widely recognized as the most severe renal-vascular complication, but also several forms of chronic renal vasculopathy and reduced renal function are complications of scleroderma. Scleroderma renal crisis, myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis, penicillamine-associated renal disease, abnormal urinalysis, alteration of vascular endothelial markers, scleroderma associated-vasculopathy with abnormal renal resistance indices and cardiorenal syndromes type 5 were also reported in SSc patients. A frequent form of renal involvement in SSc patients is a subclinical renal vasculopathy, characterized by vascular damage and normal renal function. Indeed, asymptomatic renal changes, expressed by increase of intrarenal stiffness, are often non-progressive in SSc patients but can lead to a reduction in renal functional reserve. The purpose of this review is to provide an assessment of kidney involvement in SSc, from SRC to subclinical renal vasculopathy.<br />Competing Interests: Declaration of Competing Interest The author has no financial or other conflicts of interest to disclose.<br /> (Copyright © 2022 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1538-2990
- Volume :
- 364
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The American journal of the medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 35537505
- Full Text :
- https://doi.org/10.1016/j.amjms.2022.02.014