Understanding binding affinity and specificity of modular protein domains: A focus in ligand design for the polyproline-binding families.

Authors :: Martinez JC
Castillo F
Ruiz-Sanz J
Murciano-Calles J
Camara-Artigas A
Luque I
Source :: Advances in protein chemistry and structural biology [Adv Protein Chem Struct Biol] 2022; Vol. 130, pp. 161-188. Date of Electronic Publication: 2022 Jan 10.
Publication Year :: 2022
Abstract: Within the modular protein domains there are five families that recognize proline-rich sequences: SH3, WW, EVH1, GYF and UEV domains. This chapter reviews the main strategies developed for the design of ligands for these families, including peptides, peptidomimetics and drugs. We also describe some studies aimed to understand the molecular reasons responsible for the intrinsic affinity and specificity of these domains.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)

Subjects :: Binding Sites
Humans
Ligands
Protein Binding
Protein Domains
Peptides chemistry
Proline chemistry
Proline metabolism

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