UPLC-MS-guided isolation of single ether linkage dimeric 2-(2-phenylethyl)chromones from Aquilaria sinensis .

Authors :: Kuang T
Chen HQ
Wang H
Kong FD
Cai CH
Dong WH
Yuan JZ
Mei WL
Dai HF
Source :: RSC advances [RSC Adv] 2019 May 31; Vol. 9 (30), pp. 17025-17034. Date of Electronic Publication: 2019 May 31 (Print Publication: 2019).
Publication Year :: 2019
Abstract: Eleven novel uncommon single ether linkage dimeric 2-(2-phenylethyl)chromones (aquilasinenones A-K) were isolated by a UPLC-MS guided method from artificial hole-induced agarwood originating from Aquilaria sinensis . Their structures were unambiguously deduced using HRESIMS data, detailed 1D and 2D NMR spectroscopic analysis, and experimental ECD spectra. All the compounds were tested for acetylcholinesterase (AChE) inhibitory activity by Ellman's colorimetric method, and compounds 9-11 displayed weak AChE inhibitory activity with the inhibition ranging from 15.6% to 16.8% at a concentration of 50 μg mL <superscript>-1</superscript> .<br />Competing Interests: The authors declare that they have no conflicts of interest.<br /> (This journal is © The Royal Society of Chemistry.)

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