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Protective effect of polysaccharides isolated from the seeds of Cuscuta chinensis Lam. on 5-fluorouracil-induced intestinal mucositis in mice.
- Source :
-
Acta cirurgica brasileira [Acta Cir Bras] 2022 May 02; Vol. 37 (2), pp. e370204. Date of Electronic Publication: 2022 May 02 (Print Publication: 2022). - Publication Year :
- 2022
-
Abstract
- Purpose: To evaluate the protective effect of Cuscuta chinensis Lam. polysaccharides (PCCL) on 5-fluorouracil-(5-FU)-induced intestinal mucositis (IM) in mice.<br />Methods: PCCL was orally administered at a dose of 20 mg·kg-1 for 7 days and its protective effect on 5-FU-induced IM (5-FU, 50 mg·kg-1 for 5 days) was evaluated by monitoring changes in body weight, degree of diarrhea, levels of tissue inflammatory factors (tumor necrosis factor α, interleukin 6, and interleukin 1β levels), apoptosis rates, and the expression levels of caspase-3, Bax and Bcl-2.<br />Results: The severity of mucosal injury (as reflected by body weight changes, degree of diarrhea, height of villi, and damage to crypts) was significantly attenuated by PCCL administration. PCCL also reduced the levels of tissue inflammatory factors, the apoptosis rate, and the expression of caspase-3 and Bax, and increased Bcl-2 expression.<br />Conclusions: PCCL administration may be significantly protective against 5-FU-induced IM by inhibiting apoptosis and regulating the abnormal inflammation associated with it.
- Subjects :
- Animals
Antimetabolites, Antineoplastic adverse effects
Body Weight
Caspase 3 metabolism
Diarrhea chemically induced
Diarrhea drug therapy
Diarrhea pathology
Fluorouracil adverse effects
Intestinal Mucosa pathology
Mice
Polysaccharides pharmacology
Polysaccharides therapeutic use
Seeds
bcl-2-Associated X Protein metabolism
Cuscuta metabolism
Mucositis chemically induced
Mucositis drug therapy
Mucositis prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1678-2674
- Volume :
- 37
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta cirurgica brasileira
- Publication Type :
- Academic Journal
- Accession number :
- 35507968
- Full Text :
- https://doi.org/10.1590/acb370204