Partial efficacy of a Brazilian coralsnake antivenom and varespladib in neutralizing distinct toxic effects induced by sublethal Micrurus dumerilii carinicauda envenoming in rats.

Authors :: Silva-Carvalho R
Gaspar MZ
Quadros LHB
Lobo LGG
Giuffrida R
Santarém CL
Silva EO
Gerez JR
Silva NJ Jr
Hyslop S
Lomonte B
Floriano RS
Source :: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2022 Jul 15; Vol. 213, pp. 99-104. Date of Electronic Publication: 2022 Apr 27.
Publication Year :: 2022
Abstract: In this work, we reported the efficacy of a combination of Brazilian therapeutic coralsnake antivenom (CAV) and varespladib (phospholipase A <subscript>2</subscript> inhibitor - VPL) in partially neutralizing selected toxic effects of Micrurus dumerilii carinicauda coralsnake venom in rats. Venom caused local myonecrosis and systemic neurotoxicity, nephrotoxicity, and hepatotoxicity within 2 h of injection. CAV and VPL administered separately failed to prevent most of these alterations. However, a combination of CAV plus VPL offered variable protection against venom-induced coagulation disturbances, leukocytosis, and renal-hepatic morphological alterations.<br /> (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Subjects :: Acetates
Animals
Antivenins pharmacology
Brazil
Elapid Venoms toxicity
Indoles
Keto Acids
Rats
Coral Snakes

Language :: English
ISSN :: 1879-3150
Volume :: 213
Database :: MEDLINE
Journal :: Toxicon : official journal of the International Society on Toxinology
Publication Type :: Academic Journal
Accession number :: 35489427
Full Text :: https://doi.org/10.1016/j.toxicon.2022.04.014

Full Text Access

Tools