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The multifaceted role of ATF4 in regulating glucose-stimulated insulin secretion.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2022 Jun 30; Vol. 611, pp. 165-171. Date of Electronic Publication: 2022 Apr 16. - Publication Year :
- 2022
-
Abstract
- Stress-inducible transcription factor ATF4 is essential for survival and identity of β-cell during stress conditions. However, the physiological role of ATF4 in β-cell function is not yet completely understood. To understand the role of ATF4 in glucose-stimulated insulin secretion (GSIS), β-cell-specific Atf4 knockout (βAtf4KO) mice were phenotypically characterized. Insulin secretion and mechanistic analyses were performed using islets from control Atf4f/f and βAtf4KO mice to assess key regulators for triggering and amplifying signals for GSIS. βAtf4KO mice displayed glucose intolerance due to reduced insulin secretion. Moreover, βAtf4KO islets exhibited a decrease in both the insulin content and first-phase insulin secretion. The analysis of βAtf4KO islets showed that ATF4 is required for insulin production and glucose-stimulated ATP and cAMP production. The results demonstrate that ATF4 contributes to the multifaceted regulatory process in GSIS even under stress-free conditions.<br />Competing Interests: Declaration of interests The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The authors have no conflicts of interest to declare.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 611
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 35489203
- Full Text :
- https://doi.org/10.1016/j.bbrc.2022.04.038