Back to Search Start Over

Multiple Sclerosis Biomarker Candidates Revealed by Cell-Type-Specific Interactome Analysis.

Authors :
Yurduseven K
Babal YK
Celik E
Kerman BE
Kurnaz IA
Source :
Omics : a journal of integrative biology [OMICS] 2022 May; Vol. 26 (5), pp. 305-317. Date of Electronic Publication: 2022 Apr 27.
Publication Year :
2022

Abstract

Multiple sclerosis (MS) is a demyelinating disorder that affects multiple regions of the central nervous system such as the brain, spinal cord, and optic nerves. Susceptibility to MS, as well as disease progression rates, displays marked patient-to-patient variability. To date, biomarkers that forecast differences in clinical phenotypes and outcomes have been limited. In this context, cell-type-specific interactome analyses offer important prospects and hope for novel diagnostics and therapeutics. We report here an original study using bioinformatic analysis of MS data sets that revealed interaction profiles as well as specific hub proteins in white matter (WM) and gray matter (GM) that appear critical for disease mechanisms. First, cell-type-specific interactome analyses suggested that while interactions within the WM were focused on oligodendrocytes, interactions within the GM were mostly neuron centric. Second, hub proteins such as APP, EGLN3, PTEN, and LRRK2 were identified to be differentially regulated in MS data sets. Lastly, a comparison of the brain and peripheral blood samples identified biomarker candidates such as NRGN, CRTC1, CDC42, and IFITM3 to be differentially expressed in different types of MS. These findings offer a unique cell-type-specific cell-to-cell interaction network in MS and identify potential biomarkers by comparative analysis of the brain and the blood transcriptomics. From a study design and methodology perspective, we suggest that the cell-type-specific interactome analysis is an important systems science frontier that might offer new insights on other neurodegenerative and brain disorders as well.

Details

Language :
English
ISSN :
1557-8100
Volume :
26
Issue :
5
Database :
MEDLINE
Journal :
Omics : a journal of integrative biology
Publication Type :
Academic Journal
Accession number :
35483054
Full Text :
https://doi.org/10.1089/omi.2022.0023