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T2-fluid-attenuated inversion recovery mismatch sign in lower grade gliomas: correlation with pathological and molecular findings.
- Source :
-
Brain tumor pathology [Brain Tumor Pathol] 2022 Apr; Vol. 39 (2), pp. 88-98. Date of Electronic Publication: 2022 Apr 28. - Publication Year :
- 2022
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Abstract
- After the new molecular-based classification was reported to be useful for predicting prognosis, the T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign has gained interest as one of the promising methods for detecting lower grade gliomas (LGGs) with isocitrate dehydrogenase (IDH) mutations and chromosome 1p/19q non-codeletion (IDH mut-Noncodel) with high specificity. Although all institutions could use T2-FLAIR mismatch sign without any obstacles, this sign was not completely helpful because of its low sensitivity. In this study, we attempted to uncover the mechanism of T2-FLAIR mismatch sign for clarifying the cause of this sign's low sensitivity. Among 99 patients with LGGs, 22 were T2-FLAIR mismatch sign-positive (22%), and this sign as a marker of IDH mut-Noncodel showed a sensitivity of 55.6% and specificity of 96.8%. Via pathological analyses, we could provide evidence that not only microcystic changes but the enlarged intercellular space was associated with T2-FLAIR mismatch sign (pā=ā0.017). As per the molecular analyses, overexpression of mTOR-related genes (m-TOR, RICTOR) were detected as the molecular events correlated with T2-FLAIR mismatch sign (pā=ā0.020, 0.030. respectively). Taken together, we suggested that T2-FLAIR mismatch sign could pick up the IDH mut-Noncodel LGGs with enlarged intercellular space or that with overexpression of mTOR-related genes.<br /> (© 2022. The Author(s), under exclusive licence to The Japan Society of Brain Tumor Pathology.)
Details
- Language :
- English
- ISSN :
- 1861-387X
- Volume :
- 39
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Brain tumor pathology
- Publication Type :
- Academic Journal
- Accession number :
- 35482260
- Full Text :
- https://doi.org/10.1007/s10014-022-00433-6