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Novel developed HPLC analyses of [ 68 Ga]Ga/[ 177 Lu]Lu-EDTMP and [ 68 Ga]Ga/[ 177 Lu]Lu-DOTA-Zoledronate.
- Source :
-
Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2022 Jun 15; Vol. 65 (7), pp. 178-186. Date of Electronic Publication: 2022 Apr 27. - Publication Year :
- 2022
-
Abstract
- Radiolabeled phosphonates have found widespread applications in nuclear medicine for the treatment of bone metastases. Even though considerable attention has been devoted to the administration of radiolabeled phosphonates to the patients, quality control (QC) studies belong to detection of them are still speculative and need to be improved. Herein, practical, efficient, and more reliable high-performance liquid chromatograpy (HPLC) methods were described for the first time. Radiochemical purity was easily determined by our developed analytical methods. N,N-Dimethylhexylamine and N,N-dimethyltetradecylamine were furnished as suitable ion pair reagents for the identification of radiopharmaceutical products. Effects of column type, pH of the mobile phase, and salt concentration were also examined.<br /> (© 2022 John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1099-1344
- Volume :
- 65
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of labelled compounds & radiopharmaceuticals
- Publication Type :
- Academic Journal
- Accession number :
- 35466456
- Full Text :
- https://doi.org/10.1002/jlcr.3972